NOTCH4 and hepatocellular carcinoma: In the context of our study, interesting results have been obtained by Ahn et al., who demonstrated that in patients with hepatocellular carcinoma, the high expression of Notch4 is correlated with low Edmondson grade, low AJCC T-stage, lack of microvascular invasion, absence of intrahepatic metastases and low serum AFP levels [12].