Other miRNAs that can negatively affect insulin secretion from pancreatic beta-cells include miR-124a, which targets Guanosine triphosphatase Ras-associated binding protein 27a (GTPases Rab27a) and Forkhead box protein A2 (FOXA2) promoting T2DM through beta-cell dysfunction (Figure 1) [44,45]. This evidence concerns the gene INS and type 2 diabetes mellitus.