During hyperglycemia, miR-182-5p plays an essential role in suppressing gluconeogenesis by affecting insulin-like growth factor-1 (IGF1) and its receptor and subsequently stimulating the phosphoinositide-3-kinase-protein kinase/akt (PI3K/Akt) signaling pathway and FOXO1 [46]. This evidence concerns the gene AKT1 and Hyperglycemia.