In PCa, the binding of the Wnt ligand with its receptor Frizzled and lipoprotein receptor-related protein (LRP)5/6 results in the stabilization and nuclear translocation of β-catenin, which acts as a cofactor of the T-cell factor/lymphoid enhancer factor (TCF/LEF) transcription factor family to regulate PCSC-related genes such as CD44 [113]. This evidence concerns the gene CD44 and posterior cortical atrophy.