In this study, the authors utilized the ATAC-seq from 40 metastatic prostate cancer models (twenty-two patient-derived organoids, six patient-derived xenografts, seven cell lines and five neuroendocrine PCa patients) as inputs to perform clustering consensus analysis based on the top variable chromatin accessible peaks, leading to the identification of four molecular sub-types of CRPC: AR-dependent PCa (CRPC-AR), cancer stem-like PCa (CRPC-SCL), neuroendocrine PCa (CRPC-NE) and Wnt-dependent PCa (CRPC-Wnt). Here, AR is linked to prostate cancer.