Interestingly, a recent Science article demonstrated that PCa can be classified into four sub-types according to the molecular signature: AR-dependent PCa, cancer stem-like PCa, neuroendocrine PCa and Wnt-dependent PCa, highlighting the heterogeneous role of Wnt signaling in driving PCa progression, in addition to its definite role in the regulation of PCSC biology [119]. This evidence concerns the gene AR and cancer.