A role of the RAS and the AT2R in PAH/PH is also supported by findings that activation of angiotensin-converting enzyme-2 (ACE2), which catalyzes the production of Ang-(1-7) and Ang-(1-7) per se ameliorate experimental pulmonary hypertension in the rat [17,18,19,20]. This evidence concerns the gene ANG and pulmonary arterial hypertension.