In line with our results, PER2 and PER3 were increased, most noticeably when collected between 4 pm and 9 pm for PER2 and between 9 am and 9 pm for PER3, in peripheral blood mononuclear cells from asthma patients (unpublished results, scientific meeting abstracts [21,22]). The gene discussed is PER3; the disease is asthma.