CLOCK and allergic rhinitis: Using recently published transcriptome data of peripheral blood mononuclear cells (PBMCs) from individuals with pediatric/adolescent asthma [10], we found that these patients could be classified into three circadian cluster (CC) subtypes based on the expression patterns of seven core circadian genes (CLOCK, BMAL1, PER1-3, CRY1-2) that have transcriptomic distribution and were associated with different frequencies of two asthma comorbidities: allergic rhinitis and atopic dermatitis.