Many studies have reported that numerous enzymes involved in lipogenesis are up-regulated in HCC nodules, including the ATP citrate lyase (ACLY) [86,87], the acetyl-CoA carboxylase (ACC) [87,88], the fatty acid synthase (FASN) [86] and the stearoyl-CoA-desaturase 1 (SCD1) [89]. This evidence concerns the gene ACLY and hepatocellular carcinoma.