Concerning glutamine homeostasis, up-regulation of the specific transporter ASCT2 (SLC1A5) or the more generic L-type amino acid transporter 1 (LAT1, also known as SLC7A5), was observed in HCC tissue compared with adjacent non-tumor tissue, correlating with tumor size [135,138,139]. The gene discussed is SLC7A5; the disease is neoplasm.