HCC is also characterized by an up-regulation of genes involved in cholesterol biosynthesis (HMG-CoA reductase –HMGCR-, mevalonate kinase –MVK-, squalene epoxidase –SQLE-) and catabolism (cholesterol 7 alpha-hydroxylase -CYP7A1-) correlating with poor prognosis [102,103,104]. The gene discussed is SQLE; the disease is hepatocellular carcinoma.