IL10 and hepatocellular carcinoma: In obesity-associated HCC mouse models, PGE2 production suppresses antitumor immunity through the prostaglandin E2 receptor 4 (EP4) on immune cells, dampening the production of pro-inflammatory mediators, such as IFNγ and TNFα, and stimulating the production of anti-inflammatory cytokines (e.g., IL10) and tumor-promoting cytokines (e.g., IL6) [195].