In an interesting study, Ma et al. showed that the release of free linoleic acid (C18:2) by lipid-laden hepatocytes causes more mitochondrially-derived oxidative damage than other free FAs and mediates selective intrahepatic CD4+ T lymphocyte cell-death without any involvement of intrahepatic NK T cells or intrahepatic CD8+ T lymphocytes in NAFLD-related HCC [193]. The gene discussed is CD8A; the disease is hepatocellular carcinoma.