Elevated levels of sCD40L have been found in several infectious diseases, including Pseudomonas aeruginosa infection in cystic fibrosis patients [125], visceral leishmaniasis caused by Leishmania infantum [126], meningococcal sepsis [127], DENV-2 [45], HIV [128], and periodontopathogens infections [129]. This evidence concerns the gene CD40LG and infection.