In the present study, HOMA-IR, a surrogate of insulin resistance or T2DM, which represents an IDF diagnostic criterion for metabolic syndrome [30], was associated with many sphingolipids with the highest VIP scores (i.e., DHCer 18:0, DHCer 24:1, Cer 18:0, Cer 24:1, SM 18:1 and SM 18:0). This evidence concerns the gene VIP and type 2 diabetes mellitus.