Mimouni et al. identified six genes that are hypomethylated in PCOS patients, including TIT1 (involved in DNA methylation), ROBO-1 (axon guidance), CDKN1A (inhibition of cell proliferation), two insulin signaling-associated genes (IGFBPL1 and IRS4) and inflammation (HDC) [160]. This evidence concerns the gene INS and polycystic ovary syndrome.