A further recent GWAS data analysis revealed that rs12478601, rs2059807, rs4784165, and rs2479106 were found on the introns of THADA, INSR, TOX3, and DENND1A, respectively, suggesting that they may be involved in the progression of PCOS in association with IR and other metabolic disorders [157]. The gene discussed is INSR; the disease is polycystic ovary syndrome.