When evaluating the relevance of metabolites to individual circuits (see Table S2), a special focus has been made in those relevant to BRCA, such as NF-KB, PPAR, ErbB, TNF, Estrogen signaling and others relevant to cancer in general, such as MAPK, Ras, Wnt, p53, PI3K-Akt, mTor signaling or Chemokines and inflammatory processes. This evidence concerns the gene TP53 and cancer.