For example, we have detected 1-methylnicotinamide (p-value 8.03 × 10−7, but also detected by metabolomics analysis), functionally; MNA (methylnicotinamide) induces T-cells to secrete the tumor-promoting cytokine tumor necrosis factor alpha, being an immune regulatory metabolite in ovarian cancer [65]. The gene discussed is TNF; the disease is ovarian carcinoma.