RLRs detect long and short dsRNA and 5′triphosphate RNA, inducing pTBK1-dependent IFN-I transcription; NLRs detect peptidoglycan component (iE-DAP) and intracellular muramyl dipeptide (MDP); cGAS recognizes viral dsDNA and tumor-derived DNA, producing cyclic dinucleotides that bind the stimulator of interferon genes (STING), inducing IFN-I transcription [4,5,6,7,8,9] (Figure 1). This evidence concerns the gene STING1 and neoplasm.