In addition, Reactome analysis suggested the enrichment of genes in the degradation of extracellular matrix, laminin interactions, defective human beta-1,3-glucosyltransferase like protein (B3GALTL) in Peters plus Syndrome (Pps), integrin cell surface interactions, interferon gamma signaling, interferon alpha/beta signaling, maturation of nucleoprotein, O-glycosylation of thrombospondin type 1 repeat (TSR) domain-containing proteins, and collagen biosynthesis and modifying enzymes (Figure 4b, Supplementary Table S7). The gene discussed is LAMB2; the disease is Peters plus syndrome.