As compared with untreated HCT-116 cells, there was a significant increment of anti-apoptotic Bcl-2 protein expression in CRC cells treated with spent media from unstimulated-RAW264.7 cells with a parallel upregulation of Bax expression (1.03- and 1.42-fold increase, respectively) (Figure 4A). The gene discussed is BCL2; the disease is colorectal carcinoma.