AKT1 and hypertrophic cardiomyopathy: In addition, the downregulated DEGs were found to be enriched In the GO terms ventricular cardiac muscle tissue morphogenesis, canonical Wnt signaling pathway, transition between fast and slow fiber, etc., and the KEGG pathways hypertrophic cardiomyopathy, dilated cardiomyopathy, circadian rhythm, PI3K-Akt signaling pathway, protein digestion and absorption, etc. (Figure S2).