This allows the detection of lncRNAs by non-invasive techniques through the use of liquid biopsies, such as urine and saliva, and less-invasive methods, such as serum and plasma [40], as has been reported for lncRNAs HOTAIR [8] and H19 [9] in breast cancer, as well as for MALAT1, which has been shown to be a serological marker in breast cancer [36] and a diagnostic biomarker for oral squamous cell carcinoma that can be detected by saliva testing [81]. This evidence concerns the gene MALAT1 and breast carcinoma.