Another example of the potential use of lncRNAs in cancer therapy is their use as targeted therapies for the treatment of metastatic cancer with the use of systems of release, such as the MALAT-1 antisense oligonucleotide, stabilized in antisense oligonucleotide-loaded nanostructure, co-functionalized in Au nanoparticles, which reduced metastatic tumors in vivo [163]. This evidence concerns the gene MALAT1 and cancer.