Importantly, in the present study, we have described that rs73572039, rs12978931 and rs11667640 in PVRL2 are associated with those lipid parameters that define atherogenic dyslipidemia, such as the number of VLDL particles and TG, HDLc and RLPc levels both in subjects with mild cognitive impairment and in subjects with high cardiometabolic risk. Here, NECTIN2 is linked to Cognitive impairment.