Finally, Chadwick and colleagues demonstrated that MR antagonism by Spiro was able to downregulate the Ankrd1 transcript, a sarcomeric component that is altered in several muscle diseases [55], as observed in a Duchenne muscular dystrophy (DMD) mouse model, thus identifying this adaptor protein as a novel MR gene target [22]. Here, ANKRD1 is linked to Duchenne muscular dystrophy.