Even though the pathophysiological consequences of this DJ-1–GAPDH interaction remain elusive, knockdown of DJ-1 or expression of the PD-associated DJ-1 variant, L166P, resulted in the absence of this complex, suggesting a possible modulation of the glycolytic pathway by DJ-1 through its interaction with GAPDH [63]. The gene discussed is PARK7; the disease is Parkinson disease.