Finally, the high efficacy in neuroblastoma of DNA-topoisomerase I inhibitors (e.g., camptotechin and its derivatives irinotecan and topotecan) was demonstrated decades ago [63,64,65]; at the same time, there were many chemical–chemical and chemical–natural combinations tested to manage tumor resistance or to obtain synergistic activity [66,67,68]. The gene discussed is TOP1; the disease is neuroblastoma.