DYRK2 and neoplasm: In conclusion, while in silico studies indicated five vegetal compounds from the human diet, verbascoside, lariciresinol, pinoresinol, medioresinol, and matairesinol, with potential activity against DYRK2 and neuroblastoma, in vitro MTS assays suggested caffeic acid’s potential inhibitory activity against the proliferation of tumor brain cells, and at the same time potential stimulatory activity upon normal astrocytes in humans.