WFS1 and Wolfram-like syndrome: In contrast, non-truncating/non-inactivating variants, most of which are located in the C-terminal protein domain, have been found in nonsyndromic HL families [26] or in Wolfram-like syndrome [25,27] WFS1 variants, present in five patients in our study, were missense modifications, and three of these were located in the C-terminal domain.