TP53 and cancer: In addition, a number of pathways involved in DNA damage and repair were upregulated such as DNA replication (p = 5.57 × 10−5), mRNA surveillance (p = 0.0012), nucleotide excision repair (p = 0.0033), mismatch repair (p = 0.0102), p53 signalling (p = 0.0155) and transcriptional misregulation in cancer (p = 0.0425).