We have previously found EphB4 protein levels, which are over-expressed in Malignant Mesothelioma cell lines recapitulating the three known histological types, to be tightly dependent on an intact autocrine IGF-II signal [26], with blocking of the secreted growth factor leading to a rapid and marked decrease in EphB4. The gene discussed is IGF2; the disease is malignant mesothelioma.