When the inflammatory response initially occurs, keratinocytes, innate immune cells, dendritic cells, and inflammatory cytokines such as Interleukin-1 alpha (IL-1α), tumor necrosis factor-α (TNF-α), and Interleukin 6 (IL-6) are released by activated mast cells to cause chemokines of chemotaxis, which draw immune cells to areas of injury and infection [4]. This evidence concerns the gene TNF and infection.