On the other hand, human epidermal growth factor receptor-2 (HER-2), also known as c-Neu/ErbB2, has shown a profound effect on the pathophysiology of various cancers, most importantly, breast cancer; however, recent studies have already warned that its role in other ranges of cancers cannot be denied [6,7,8,9,10]. The gene discussed is ERBB2; the disease is breast carcinoma.