IGF1 and infection: At the same time, clot formed by platelet activation can release a variety of growth factors, such as epidermal growth factor (EGF), platelet-derived growth factor (PDGF), insulin-like growth factor 1 (IGF-1), and transforming growth factor-β (TGF-β), which diffuse into surrounding tissues and recruit inflammatory cells to remove the injury factors (such as foreign bodies) and necrotic tissues at the wound site to prevent infection [19,20].