ADAM17 and chronic kidney disease: However, in CKD patients, the mRNA expression of ADAM17 is upregulated in the glomerular parietal epithelium and podocytes, and a de novo expression is observed in the glomerular endothelium and mesangium, peritubular capillaries, and proximal tubules in the kidneys compared to healthy individuals, indicating that disease development has a major influence on ADAM17 expression [59,152].