The shedding of additional transmembrane proteins has also been shown to influence the morphology of the kidney, for example, cleavage of CXCL16 by ADAM10 led to lupus nephritis and acute tubular necrosis [107,108], whereas IL6-R shedding by ADAM10/17 resulted in acute crescentic glomerulonephritis and lupus nephritis [114], and Notch shedding by ADAM10/17 led to renal fibrosis and glomerulosclerosis [164,168]. This evidence concerns the gene ADAM10 and glomerulosclerosis.