In terms of nutrition (Figure 2B), the anti-tumor effect of the ketone bodies acetoacetate and βHB has been shown in several colon and breast cancer lines in vitro through glycolysis inhibition and the over-expression of uncoupling protein 2 (UCP2), which also inhibits mitochondrial ATP generation, leading to a consequent reduction of ATP concentration [72]. This evidence concerns the gene UCP2 and breast carcinoma.