Conditioned media from BC-treated activated fibroblasts also inhibited colon cancer cell invasiveness, migration, and the epithelial-mesenchymal transition (EMT) in a human colon cancer cell line (HCT116) through the downregulation of transforming growth factor β1 (TGF-β1) and α-SMA, and the upregulation of E-cadherin. This evidence concerns the gene ACTA1 and malignant colon neoplasm.