Impairing autophagy at the autophagosome maturation stage due to p62 accumulation and the increased ratio of GFP-LC3/RFP-LC3Suppression of colon cancer invasion via CaMKKβ-AMPK-mTOR signaling cascades pathway and NF-κB pathways. The gene discussed is NFKB1; the disease is malignant colon neoplasm.