Moreover, it was shown that inhibition of mTOR improves ASD-like behaviours related to Tsc2 or Tsc1 haploinsufficiency (in several Tsc1+/− or Tsc2+/− animal models), pointing to mTOR attenuation as an effective strategy in various mTOR-related brain dysfunctions, including autism [1,2,25,28,29,30,31]. Here, TSC1 is linked to autism.