Basal BVRA protein levels are positively associated with fasting insulin and indexes of increased insulin resistance and insulin secretion, such as HOMA-IR, HOMA-β, and the insulinogenic index, a validated indicator of acute beta cell response (first-phase insulin secretion: (BI30-FBI0)/(BG30-FBG) (Figure 2A–D). The gene discussed is INS; the disease is Insulin resistance.