Reduction in BVRA protein levels was linked to abnormal activation of the IR/IRS1/AKT/GSK3β/GLUT4 pathway, which was related to poor glycometabolic control, as well as the presence of metabolic syndrome, liver steatosis, and inflammation of visceral adipose tissue in individuals with obesity and T2D [29,30,31,32]. This evidence concerns the gene BLVRA and obesity due to melanocortin 4 receptor deficiency.