Notably, NPC proteins from HF blood displayed enriched GO terms with lg p > 5, such as “protein-DNA complex”, terms associated with the replication fork (“replisome”, “nuclear replisome”, “nuclear replication fork”, and “replication fork”), and terms associated with chromosomes (“chromosomal part”, “nuclear chromosomal part”, “chromosome”, “nuclear chromosome”). Here, NPC1 is linked to hydrops fetalis.