TF and blood coagulation disease: CAC had been initially assimilated to a disseminated intravascular coagulopathy (DIC) but is currently recognized to be a specific coagulopathy characterized by elevated plasmatic levels of von Willebrand factor (vWF), soluble P-selectin (sP-selectin), tissue factor (TF), tissue factor pathway inhibitor (TFPI), and thrombin–antithrombin complexes (TAT).