According to our data, the downregulation in these genes and their eventual signaling (Fgfr2, Mapk1/3, Bmp4, and Ctnnb1) appears to be an early bone response to mild CKD, concurrently with histological features of lower bone turnover in Nx2 and Nx6 (vs. SO6 and SO2). The gene discussed is CTNNB1; the disease is chronic kidney disease.