PTEN and neoplasm: In this sense, various oncomiRs have been demonstrated to be overexpressed, including miR-21 (an inhibitor of PTEN—Phosphatase and tensin homolog), miR-155 (targeting of p53) and miR-424-5p (downregulates SOCS6 and stimulates the Ras-ERK pathway to favor tumor proliferation), whereas the decreased expression of tsmiRs such as miR-203 (involved in the loss of regulation of cell proliferation in the G1 phase due to alterations in SOCS3) is also implicated in cell cycle dysregulation [43].