TGFB1 and pulmonary fibrosis: D’Alessandro-Gabazza et al. [31] reported that a knockdown of TGF-β1 inhibits spontaneous lung fibrosis and improves survival in bleomycin-induced pulmonary fibrosis in mice with a significant decrease in ECM deposition; this indicates that TGF-β1 may be a major factor in inducing fibrosis in the lungs.