During diabetes development, the expression level of TRPC6 channels and agonist-stimulated Ca2+ response is increased (Figure 5, Figure 6 and Figure 7A), which might lead to the basal accumulation of Na+ within the cell, cell depolarization and an earlier contribution of Ca2+ influx through NCX (Figure 4C and Figure 7A). The gene discussed is TLX2; the disease is diabetes mellitus.