TRPC6 and diabetes mellitus: In podocytes from rats with diabetes, we observed that basal TRPC6 activity was slightly increased (NPomax30 = 0.5 ± 0.1), while the influence of Ca2+ store depletion on TRPC6 activity was negligible (NPomax30 = 0.3 ± 0.1, Figure 4B,D).