ALB and Alzheimer disease: Some pathological features of BBB breakdown in AD brains include the extravasation of blood-derived proteins (fibrinogen, thrombin, plasminogen, immunoglobin C, albumin) in the hippocampus and cortex, an increase in the CSF levels of a pericyte injury marker, an increase in the CSF-to-plasma-albumin ratio, iron accumulation, and brain microbleeds [76,117].