IL6 and asthma: Although the pathogenesis of type 2-low asthma is not completely elucidated, the following mechanisms have been suggested to play a role in this subtype of asthma: (i) type 1 (IFN-mediated) and type 3 (IL-17-mediated) immune pathways together with airway neutrophilia; (ii) pauci-granulocytic mechanisms; (iii) systemic inflammation associated with IL-6, obesity, and metabolic dysfunction [32].