IL5 and asthma: Data from mouse models, also confirmed in asthmatic patients, show that among asthma phenotypes there may be a different expression of eosinophil subpopulation differing from their localization (parenchymal/peribronchial), cellular density profiles (hypodense/normodense), asthma endotypes (allergic/non allergic eosinophilic), surface adhesion capacity, and responsiveness to IL-5 [29].