These data, on the one hand confirm the strong correlation between sputum eosinophilia and OCS dependence, and on the other hand, are in line with the observation of the incomplete reduction in eosinophils in blood and tissues in IL-5 or IL5-Rα knockout mouse model, suggesting that IL-5 may not be the only driver of eosinophilia [154]. Here, IL5RA is linked to Increased total eosinophil count.