This isoform has also been connected with different neurodegenerative disorders; the inhibition of the NOX2 enzyme alleviated symptoms of Alzheimer’s disease (AD), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS) in mice models [63], and its increased expression was detected in the post-mortem brains samples of traumatic brain injury (TBI) victims [68]. The gene discussed is CYBB; the disease is early-onset autosomal dominant Alzheimer disease.