The downregulation of ENT1, the main transporter regulating the cellular uptake of gemcitabine, has also been pointed to as an EMT-mediated chemoresistance mechanism, as recently demonstrated in pancreatic tumor cells, where the E- to N-cadherin switching initiated by EMT negatively influenced the expression of ENT1, cell surface location, and transport function, leading to gemcitabine resistance [30]. Here, CDH2 is linked to pancreatic neoplasm.