ATP5F1A and Parkinson disease: Genomic studies performed on peripheral blood showed the down-regulation of genes critical for mitochondrial functions (COX4I1, ATP5A1, and VDAC3) [232], while the analysis of blood-circulating extracellular vesicles demonstrated the reduction in mitochondrial components (i.e., ATP5A, NDUFS3, and SDHB) in PD patients [233].