HLA-DQB1 and cranioectodermal dysplasia: However, up to 90% of CeD patients carry HLA-DQ2.5 alleles (HLA-DQA1*05:01 and HLA-DQB1*02:01), while the rest express either HLA-DQ2.2 (HLA-DQA1*02:01 and HLA-DQB1*02:02; ~5%) or HLA-DQ8 (HLA-DQA1*03:01 and HLA-DQB1*03:02) alleles, and around 20% of the CeD patients are homozygous for HLA-DQ2 alleles [15,16].