Among the AT SEVs activated signaling pathways in BC cells are Hippo [203], HIF-1α [202], ERK [204], Wnt/β-catenin [205], JAK/STAT3 [206], PI3K/AKT, and TGFbeta/Smad [207] (For review, [208]). This evidence concerns the gene TGFB1 and breast cancer.