Comparative proteome analysis of circulating SEVs in healthy and BC patients has shown that the association of three favorable (Serpin A1 (SERPINA1), keratin 6 (KRT6B), and SOCS3) and one unfavorable (insulin growth factor 2 receptor (IGF2R)) SEV protein markers allow diagnosing with 73% sensitivity and 100% specificity BC stage I and II [495]. This evidence concerns the gene SERPINA1 and breast cancer.