Enzymes and specific signaling proteins (EpCAM, EFGR, and survivin-2B) along with metalloproteinase ADAM10, heat-shock protein HSP70, and Annexin-1 can also be evidenced as general marker proteins detected in serum and pleural effusion-derived SEVs from BC cell lines or BC patients [237,498]. The gene discussed is ANXA1; the disease is breast cancer.