To evade the immune system, tumors release immunosuppressive cytokines (e.g., TGF-β, interleukins IL8, IL6, IL10, etc.)and skew the tumor microenvironment to a more immunosuppressive one through either inhibiting CD8+ T cells, NK cells, dendritic cell maturation or increasing Tregs and tumor-associated macrophages (TAMs) [269]. The gene discussed is CD8A; the disease is neoplasm.