Regardless, very interestingly, it was shown that the synthesis of the monocytic IL-6 cytokine and STAT-3 phosphorylation is mediated by the CCR1 receptor, which is also linked to secretion of the IL-8 cytokine [76], which demonstrates enhanced IL-6 and IL-8 production and increased monocytic CCR1 expression among the postoperative CAD cohort, corroborating our findings. This evidence concerns the gene CXCL8 and coronary artery disorder.