As subgrouping of blood circulating monocytes has been widely acknowledged since 2010, based on the cell surface expression of CD14 and CD16, dictating into (i) classical monocytes (CD14highCD16dim), (ii) intermediate monocytes (CD14IntCD16Int), and (iii) non-classical monocytes (CD14dimCD16high) [17,18], there were several reports demonstrating increased numbers of circulating inflammatory monocytes in association with plaque progression [19], sustaining coronary atherosclerosis [20,21] and CAD prevalence [22]. Here, CD14 is linked to coronary artery disorder.