SNCA and synucleinopathy: In mice and rats, intracerebral inoculation of recombinant α-synuclein pre-formed fibrils (PFFs), brain tissue from symptomatic α-synuclein transgenic mice, or brain tissue from human synucleinopathy patients, results in widespread deposition of LB-like inclusions that are often associated with neurodegeneration and motor dysfunction [38,40,41,42,45,46,47,50].