S1P stimulates cell proliferation and promotes invasion in colon cancer cell lines [60], and neutralizing S1P with highly specific anti-S1P monoclonal antibodies blocks S1P’s pro-survival actions (by increasing activation of Caspase-3), which was manifested by the inhibition of tumor progression and reduction of the tumor volume in human cancer models [61]. This evidence concerns the gene CASP3 and malignant colon neoplasm.