Although those studies have reported the absence of molecular signatures that could discriminate between radio-induced and non-radio-induced BCC, particularly linked to the PTCH and TP53 genes [13,43], it was suggested that the Hh signaling pathway could be linked to susceptibility to BCC radiation carcinogenesis and that PTCH could contribute to this process [43]. This evidence concerns the gene PTCH1 and skin basal cell carcinoma.