Moreover, the Reactome database explored the fibrinolysis pathway, the cell surface PLAUR role in the conversion of plasminogen to plasmin, and the effect of infection or inflammation on dissociated PLAUR from the cell surface of the endothelial cells lining the vessels forming suPAR that leads to a decrease in the fibrinolysis process, and this may explain the coagulation defect that accompanies COVID-19 infection (Figure 7B). This evidence concerns the gene PLG and infection.