The matrix showed a significant and strong positive correlation between the suPAR level and COVID-19 severity (r = 0.88) and the need for O2 therapy (r = 0.79), and a moderate positive correlation with CRP, LDH, TLC, PT, INR, and NLR (r = 0.49, 0.43, 0.43, 0.32, 0.32, and 0.31), respectively. The gene discussed is CRP; the disease is COVID-19.