ALS2 and amyotrophic lateral sclerosis: Familial ALS (FALS) represents up to 10% of total ALS cases, commonly considered an autosomal dominant inheritable disease, with ~20% of FALS cases being related to mutations in various genes, including Cu/Zn superoxide-dismutase, dynactin 1, alsin, vesicle-associated protein B, senataxin and angiogenin [7,8].