Other conditions with neuronal degeneration, such as brain inflammation, show an active role for DPP4, aminopeptidase N (EC 3.4.11.2), as well as dipeptidyl peptidases II (DPP2, E.C. 3.4.14.2), 8 (DPP8, EC 3.4.14.5) and 9 (DPP9, EC 3.4.14.5) and cytosolic AlaAP, being involved in the regulation of autoimmunity and inflammation triggered by ischemia [16]. The gene discussed is DPP7; the disease is brain inflammatory disease.