Meanwhile, miR-148 constitutes a significant biomarker not only for predicting the HCC reoccurrence, but also in HCC screening, especially in cases in which the broadly used alpha fetoprotein (AFP) is low or normal [108], whereas microRNA-148a-3p suppresses HCC progression by downregulating SMAD2 mRNA via integrating with Ago2 [47,109,110]. This evidence concerns the gene SMAD2 and hepatocellular carcinoma.