FBXW7 and hepatocellular carcinoma: More particularly, HCC resistance to sorafenib can be overpassed via targeting miR-25, which is upregulated in HCC via targeting the FBXW7 protein [138,172], while the enhancement of miR-375 action can potentially sensitize the malignant hepatocytes to sorafenib via inhibiting the cytoprotective autophagy pathway in malignant cells [170].