Similarly, it is also demonstrated that miR-23b-3p modulates the autophagy-induced drug resistance of sorafenib in the HCC HepG2 cell line, while it not only targets ATG12 but also GLS1 (glutaminase), which is related to the high exogenous glutamine that is associated with progressed disease [171]. The gene discussed is GLS; the disease is hepatocellular carcinoma.