ATG14 and hepatocellular carcinoma: More particularly interaction between ATG14 (member of class III-PI3K complex) and miR-375 is related to drug resistance (targeted or chemotherapy), including sorafenib, while it is demonstrated that the action of miR-375 on ATG14 leads to the sensitization of HCC cells to sorafenib, via suppressing the cytoprotective effect of autophagy for cancer cells [170].