NRG1 and hepatocellular carcinoma: MiR-296-5p is found significantly reduced in HCC tissues compared with the normal tissues in the tumor vicinity, with its normal/increased levels are related to a favorable prognosis, the suppression of EMT phenomenon [50] via downregulating the Nrg1/Erbb signaling pathway, and it exerts a suppressive effect on the stem cell potential of HCC cell lines [50].