TNF and metabolic dysfunction-associated steatohepatitis: Meanwhile, it has been demonstrated that the loss of miR-122 in animal models (mice) induces the brisk development of inflammation via the over-secretion of monocyte chemoattractant protein-1 and pro-inflammatory cytokines (TNF-a, IL6) [80], whereas the downregulation of miR-122 is also related with hepatocarcinogenesis and fibrosis progression in non-alcoholic steatohepatitis (NASH) [81].