An example of this therapeutic modulation in HCC is the utilization of gold nanoparticles (AuNPs) that transfer miR-326 mimic, which promote its overexpression and the inhibition of the PDK1/AKT/c-myc axis, leading to invasion–migration inhibition, increased apoptosis, and EMT modification [193]. This evidence concerns the gene AKT1 and hepatocellular carcinoma.