Meanwhile, miR-18a constitutes an oncogenic miRNA that enhances HCC cell proliferation and tumor migratory behavior via targeting Bcl2l10 [34], whereas the upregulation of miR-155-5p and miR-331-3p is correlated with HCC progression via downregulating the PI3K/Akt pathway through PTEN inhibition and E2F1 suppression, respectively [35,36]. This evidence concerns the gene PTEN and hepatocellular carcinoma.