Studies have demonstrated that the enhancement of miR-559 expression or the silencing (knockdown) of PARD3 limits the proliferation of HCC cells via autophagy inhibition, as well as inhibits neoangiogenesis via decreasing angiopoietin 2 and vascular endothelial growth factor (VEGF) expression levels [164]. This evidence concerns the gene VEGFA and hepatocellular carcinoma.