Meanwhile, the downregulation of miR-296 is also closely associated with an unfavorable prognosis in HCC patients, whereas its upregulation induces tumor growth suppression and apoptosis, as well as cell cycle downregulation, via targeting the fibroblast growth factor receptor 1 (FGFR1), which plays a key role in cell cycle progression and tumor proliferation [100]. The gene discussed is FGFR1; the disease is hepatocellular carcinoma.